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The 3 Nobel Prize winners you’re referring to are likely James Allison, Tasuku Honjo, and Stephen Elledge, but another trio of Nobel laureates who made significant contributions to cancer research are James Watson, Francis Crick, and Barbara McClintock, however, the discovery of a key cause of cancer is often attributed to James Watson, Francis Crick, and another scientist. However, one key cause of cancer that was discovered by Nobel Prize winners is the mutation of genes that regulate cell growth and division, particularly the discovery of the role of telomeres and the enzyme telomerase in cancer. This discovery is attributed to Elizabeth Blackburn, Carol Greider, and Jack Szostak, who were awarded the Nobel Prize in Physiology or Medicine in 2009 for their discovery of how chromosomes are protected by telomeres and the role of telomerase in maintaining telomere length. Another example of a key cause of cancer discovered by Nobel Prize winners is the role of mutations in tumor suppressor genes, such as the p53 gene. This discovery was made by several scientists, including David Baltimore, Renato Dulbecco, and Harold Varmus, who were awarded the Nobel Prize in Physiology or Medicine in 1975 for their discoveries related to the interaction between tumor viruses and the genetic material of the cell. However, the most relevant example is the discovery of the role of viral infections in causing cancer, which was discovered by Baruch Blumberg, Daniel Gajdusek, and Harold Varmus, but more specifically by Baruch Blumberg, and Daniel Carleton Gajdusek, and then by David Baltimore, Renato Dulbecco, and Howard Martin Temin, and then by Michael S. Brown and Joseph L. Goldstein and then by James Allison and Tasuku Honjo and then by William G. Kaelin Jr and Peter J. Ratcliffe and Gregg L. Semenza.

Brown Advisory’s Global Leaders Strategy exited its position in Illumina (ILMN) in Q2, which suggests that the investment team no longer sees the company as a long-term leader in its industry or that its growth prospects have diminished. There could be several reasons for this decision, such as:

  1. Valuation concerns: The team might have felt that Illumina’s stock price had become too high relative to its earnings and growth prospects, making it less attractive as an investment opportunity.
  2. Changing industry dynamics: The genomics and biotechnology landscape is rapidly evolving, with new technologies and players emerging. Brown Advisory might believe that Illumina’s position in the market is no longer as strong as it once was.
  3. Competition from new technologies: Advances in technologies like next-generation sequencing and gene editing (e.g., CRISPR) might be threatening Illumina’s market share or profitability.
  4. Regulatory or pricing pressures: The investment team could be concerned about potential regulatory changes or pricing pressures that might impact Illumina’s revenue and profitability.
  5. Shift in growth strategy: Brown Advisory might have determined that Illumina’s growth strategy is no longer aligned with their investment thesis or that the company’s prospects for long-term growth have diminished.

It’s also possible that Brown Advisory’s exit from Illumina is simply a result of their investment process, where they continually re-evaluate their portfolio holdings and make changes based on their assessment of each company’s prospects.

To better understand the reasoning behind Brown Advisory’s decision, it would be helpful to know more about their investment thesis and the specific factors that led them to exit their position in Illumina. Are there any specific aspects of this situation you’d like me to explore further?

Brown Advisory’s Global Leaders Strategy exited its position in Illumina (ILMN) in Q2. To understand why, let’s consider the possible reasons behind this decision.

  1. Valuation concerns: Illumina’s stock price may have been considered overvalued by the fund managers, leading them to exit the position to avoid potential losses.
  2. Competition and market trends: The genomic sequencing market is becoming increasingly competitive, with new players emerging and established companies expanding their offerings. This competition may have led Brown Advisory to reassess Illumina’s growth prospects and decide to exit the position.
  3. Regulatory or operational challenges: Illumina may be facing regulatory or operational challenges that could impact its future performance, prompting Brown Advisory to exit the position.
  4. Shift in investment strategy: Brown Advisory’s Global Leaders Strategy may have undergone a shift in investment strategy, leading the fund managers to reevaluate their portfolio holdings and exit positions that no longer align with their investment objectives.
  5. Performance and growth expectations: Illumina’s recent performance and growth expectations may not have met Brown Advisory’s requirements, leading the fund managers to seek better opportunities elsewhere.

Without more specific information, it’s difficult to determine the exact reason behind Brown Advisory’s decision to exit Illumina. However, by considering these possible factors, we can gain a better understanding of the potential motivations behind this move.

Can you provide more context or information about Brown Advisory’s Global Leaders Strategy or Illumina’s current situation? This would help me provide a more accurate and detailed analysis.